Journal: Microbiology Spectrum
Article Title: The Lysin Exebacase Has a Low Propensity for Resistance Development in Staphylococcus aureus and Suppresses the Emergence of Resistance to Antistaphylococcal Antibiotics
doi: 10.1128/spectrum.05261-22
Figure Lengend Snippet: Serial passage of MRSA strain MW2 over 28 days with exebacase, daptomycin, or vancomycin. (A) Log 2 changes in exebacase MICs for three replicate cultures treated with exebacase and the untreated control in CAMHB-HSD. (B) Log 2 changes in daptomycin MICs for three replicate cultures treated with daptomycin and the untreated control in CAMHB (+CaCl 2 ). (C) Log 2 changes in vancomycin MICs for three replicate cultures treated with vancomycin and the untreated control in CAMHB. Closed triangles, circles, and squares, three replicate treatments; open squares, untreated control.
Article Snippet: Antibiotic and exebacase MIC values against MRSA strain MW2 and MSSA strain ATCC 29213 were determined as described in CLSI standard M07-A11 ( ) as well as in CAMHB-HSD medium.
Techniques: Control